A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

Abstract

Article highlights In this review article we have covered the state-of-the-art microfluidic methodologies for the synthesis of a broad range of nanoparticle (NPs) for potential applications in the fields of biomedicine and drug delivery. Apart from the experimental methodologies, this review also details the most common multiscale simulation methods used to unravel the critical mechanisms involved in nanoparticle synthesis and their interactions with other entities. A comprehensive summary of the microfluidic techniques, divided into passive and active micro-mixing methods, have been provided, while highlighting advantages and disadvantages of individual methods. We have discussed challenges related to NPs synthesis, their application in new fields, and future perspectives.