Natural Compounds of <em>Lasia spinosa</em> (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes

Md. Mamunur Rashid; Md. Atiar Rahman; Md. Shahidul Islam; Md. Amjad Hossen; A. M. Abu Ahmed; Mirola Afroze; Alaa H. Habib; Manal M. S. Mansoury; Hend F. Alharbi; Reham M. Algheshairy; Walla Alelwani; Afnan M. Alnajeebi; Jitbanjong Tangpong; Srabonti Saha; Alaa Qadhi; Wedad Azhar

doi:10.3390/ph15121466

Pharmaceuticals (Nov 2022)

Natural Compounds of <em>Lasia spinosa</em> (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes

Md. Mamunur Rashid,
Md. Atiar Rahman,
Md. Shahidul Islam,
Md. Amjad Hossen,
A. M. Abu Ahmed,
Mirola Afroze,
Alaa H. Habib,
Manal M. S. Mansoury,
Hend F. Alharbi,
Reham M. Algheshairy,
Walla Alelwani,
Afnan M. Alnajeebi,
Jitbanjong Tangpong,
Srabonti Saha,
Alaa Qadhi,
Wedad Azhar

Affiliations

Md. Mamunur Rashid: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
Md. Atiar Rahman: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
Md. Shahidul Islam: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
Md. Amjad Hossen: Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong 4318, Bangladesh
A. M. Abu Ahmed: Department of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong 4331, Bangladesh
Mirola Afroze: Bangladesh Reference Institute for Chemical Measurements (BRiCM), Dr. Qudrat-e-Khuda Road (Laboratory Road), Dhanmondi, Dhaka 1205, Bangladesh
Alaa H. Habib: Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Manal M. S. Mansoury: Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Hend F. Alharbi: Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia
Reham M. Algheshairy: Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia
Walla Alelwani: Department of Biochemistry, Collage of Science, University of Jeddah, Jeddah 80203, Saudi Arabia
Afnan M. Alnajeebi: Department of Biochemistry, Collage of Science, University of Jeddah, Jeddah 80203, Saudi Arabia
Jitbanjong Tangpong: School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand
Srabonti Saha: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
Alaa Qadhi: Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia
Wedad Azhar: Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia

DOI: https://doi.org/10.3390/ph15121466
Journal volume & issue: Vol. 15, no. 12
p. 1466

Abstract

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Natural biometabolites of plants have been reported to be useful in chronic diseases including diabetes and associated complications. This research is aimed to investigate how the biometabolites of Lasia spinosa methanol stem (MEXLS) extract ameliorative diabetes and diabetes-related complications. MEXLS was examined for in vitro antioxidant and in vivo antidiabetic effects in a streptozotocin-induced diabetes model, and its chemical profiling was done by gas chromatography-mass spectrometry analysis. The results were verified by histopathological examination and in silico ligand-receptor interaction of characterized natural biometabolites with antidiabetic receptor proteins AMPK (PDB ID: 4CFH); PPARγ (PDB ID: 3G9E); and mammalian α-amylase center (PDB ID: 1PPI). The MEXLS was found to show a remarkable α-amylase inhibition (47.45%), strong antioxidant action, and significant (p d-galactopyranoside displayed the highest binding affinity with AMPK (docking score, −5.764), PPARγ (docking score, −5.218), and 1PPI (docking score, −5.615) receptors. Data suggest that the MEXLS may be an exciting source to potentiate antidiabetic activities affirming a cell-line study.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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