Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly

Abstract

The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-binding.