m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang; Jiangbo Wei; Yan-Hong Cui; Gayoung Park; Palak Shah; Yu Deng; Andrew E. Aplin; Zhike Lu; Seungmin Hwang; Chuan He; Yu-Ying He

doi:10.1038/s41467-019-10669-0

Nature Communications (Jun 2019)

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang,
Jiangbo Wei,
Yan-Hong Cui,
Gayoung Park,
Palak Shah,
Yu Deng,
Andrew E. Aplin,
Zhike Lu,
Seungmin Hwang,
Chuan He,
Yu-Ying He

Affiliations

Seungwon Yang: Department of Medicine, Section of Dermatology, University of Chicago
Jiangbo Wei: Departments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
Yan-Hong Cui: Department of Medicine, Section of Dermatology, University of Chicago
Gayoung Park: Department of Pathology, University of Chicago
Palak Shah: Department of Medicine, Section of Dermatology, University of Chicago
Yu Deng: Department of Medicine, Section of Dermatology, University of Chicago
Andrew E. Aplin: Department of Cancer Biology, Thomas Jefferson University
Zhike Lu: Departments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
Seungmin Hwang: Department of Pathology, University of Chicago
Chuan He: Departments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
Yu-Ying He: Department of Medicine, Section of Dermatology, University of Chicago

DOI: https://doi.org/10.1038/s41467-019-10669-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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