Crystal structure of vilazodone hydrochloride methanol monosolvate

Abstract

In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzofuran ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl− anions and methanol solvent molecules are linked by classical N—H...O and N—H...Cl hydrogen bonds, and weak C—H...O and C—H...π interactions into a three-dimensional supramolecular architecture.

Keywords

• crystal structure
• benzofuran
• indole
• piperazine
• hydrogen bonds