Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Takayuki Yamamoto; Akira Sato; Yusuke Takai; Atsushi Yoshimori; Masahiro Umehara; Yoko Ogino; Mana Inada; Nami Shimada; Aya Nishida; Risa Ichida; Ryoko Takasawa; Hiroko Maruki-Uchida; Sadao Mori; Masahiko Sai; Minoru Morita; Sei-ichi Tanuma

Biochemistry and Biophysics Reports (Dec 2019)

Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Takayuki Yamamoto,
Akira Sato,
Yusuke Takai,
Atsushi Yoshimori,
Masahiro Umehara,
Yoko Ogino,
Mana Inada,
Nami Shimada,
Aya Nishida,
Risa Ichida,
Ryoko Takasawa,
Hiroko Maruki-Uchida,
Sadao Mori,
Masahiko Sai,
Minoru Morita,
Sei-ichi Tanuma

Affiliations

Takayuki Yamamoto: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan; Corresponding author.
Akira Sato: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Yusuke Takai: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Atsushi Yoshimori: Institute for Theoretical Medicine Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-0012, Japan
Masahiro Umehara: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan
Yoko Ogino: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Mana Inada: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Nami Shimada: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Aya Nishida: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Risa Ichida: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Ryoko Takasawa: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Hiroko Maruki-Uchida: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan
Sadao Mori: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan
Masahiko Sai: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan
Minoru Morita: Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan
Sei-ichi Tanuma: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan; Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan; Corresponding author. Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.

Journal volume & issue: Vol. 20

Abstract

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Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI–H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI–H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment. Keywords: Passion fruit seed extract, Piceatannol, Glyoxalase I, Anticancer

Published in Biochemistry and Biophysics Reports

ISSN: 2405-5808 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General); Science: Chemistry: Organic chemistry: Biochemistry
Website: http://www.journals.elsevier.com/biochemistry-and-biophysics-reports/

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