Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain
Fiona Campbell,
Jennifer Stinson,
Sara E Williams,
Christopher D King,
Laura Simons,
Massieh Moayedi,
Robert C Coghill,
Martin S Angst,
Nima Aghaeepour,
Brice Gaudilliere,
Marina López-Solà,
Marie-Eve Hoeppli,
Emma Biggs,
Ed Ganio,
Kenneth R Goldschneider,
Danielle Ruskin,
Elliot J Krane,
Suellen Walker,
Gillian Rush,
Marissa Heirich
Affiliations
Fiona Campbell
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG
Jennifer Stinson
Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
Sara E Williams
Pediatric Pain Research Center, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
Christopher D King
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Laura Simons
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Massieh Moayedi
Centre for Multimodal Sensorimotor and Pain Research, University of Toronto Faculty of Dentistry, Toronto, Ontario, Canada
Robert C Coghill
Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
Martin S Angst
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Nima Aghaeepour
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Brice Gaudilliere
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Marina López-Solà
Serra Hunter Programme, Department of Medicine, University of Barcelona, Barcelona, Spain
Marie-Eve Hoeppli
Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
Emma Biggs
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Ed Ganio
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Kenneth R Goldschneider
Pediatric Pain Research Center (PPRC), Cincinnati Children`s Hospital Medical Center, Cincinnati, Ohio, USA
Danielle Ruskin
Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
Elliot J Krane
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Suellen Walker
Developmental Neurosciences Department, UCL GOS Institute of Child Health, UCL, London, UK
Gillian Rush
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Marissa Heirich
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
Introduction Current treatments for chronic musculoskeletal (MSK) pain are suboptimal. Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. Given that chronic pain is a biopsychosocial process, this study aims to discover and validate a robust prognostic signature that measures across multiple dimensions in the same adolescent patient cohort with a computational analysis pipeline. This will facilitate risk stratification in adolescent patients with chronic MSK pain and more resourceful allocation of patients to costly and potentially burdensome multidisciplinary pain treatment approaches.Methods and analysis Here we describe a multi-institutional effort to collect, curate and analyse a high dimensional data set including epidemiological, psychometric, quantitative sensory, brain imaging and biological information collected over the course of 12 months. The aim of this effort is to derive a multivariate model with strong prognostic power regarding the clinical course of adolescent MSK pain and function.Ethics and dissemination The study complies with the National Institutes of Health policy on the use of a single internal review board (sIRB) for multisite research, with Cincinnati Children’s Hospital Medical Center Review Board as the reviewing IRB. Stanford’s IRB is a relying IRB within the sIRB. As foreign institutions, the University of Toronto and The Hospital for Sick Children (SickKids) are overseen by their respective ethics boards. All participants provide signed informed consent. We are committed to open-access publication, so that patients, clinicians and scientists have access to the study data and the signature(s) derived. After findings are published, we will upload a limited data set for sharing with other investigators on applicable repositories.Trial registration number NCT04285112.
