Journal of Fungi (Mar 2024)

Just around the Corner: Advances in the Optimization of Yeasts and Filamentous Fungi for Lactic Acid Production

  • Nadielle Tamires Moreira Melo,
  • Ana Caroline de Oliveira Junqueira,
  • Letícia Ferreira Lima,
  • Kamila Botelho Sampaio de Oliveira,
  • Micaela Cristiane Gomes dos Reis,
  • Octávio Luiz Franco,
  • Hugo Costa Paes

DOI
https://doi.org/10.3390/jof10030207
Journal volume & issue
Vol. 10, no. 3
p. 207

Abstract

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Lactic acid (LA) production has seen significant progress over the past ten years. LA has seen increased economic importance due to its broadening use in different sectors such as the food, medicine, polymer, cosmetic, and pharmaceutical industries. LA production bioprocesses using microorganisms are economically viable compared to chemical synthesis and can benefit from metabolic engineering for improved productivity, purity, and yield. Strategies to optimize LA productivity in microorganisms on the strain improvement end include modifying metabolic routes, adding gene coding for lactate transporters, inducing tolerance to organic acids, and choosing cheaper carbon sources as fuel. Many of the recent advances in this regard have involved the metabolic engineering of yeasts and filamentous fungi to produce LA due to their versatility in fuel choice and tolerance of industrial-scale culture conditions such as pH and temperature. This review aims to compile and discuss metabolic engineering innovations in LA production in yeasts and filamentous fungi over the 2013–2023 period, and present future directions of research in this area, thus bringing researchers in the field up to date with recent advances.

Keywords