Towards functional maps of non-coding variants in cancer

Yihan Wang; Gary C. Hon; Gary C. Hon

doi:10.3389/fgeed.2024.1481443

Frontiers in Genome Editing (Oct 2024)

Towards functional maps of non-coding variants in cancer

Yihan Wang,
Gary C. Hon,
Gary C. Hon

Affiliations

Yihan Wang: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States
Gary C. Hon: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States
Gary C. Hon: Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, United States

DOI: https://doi.org/10.3389/fgeed.2024.1481443
Journal volume & issue: Vol. 6

Abstract

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Large scale cancer genomic studies in patients have unveiled millions of non-coding variants. While a handful have been shown to drive cancer development, the vast majority have unknown function. This review describes the challenges of functionally annotating non-coding cancer variants and understanding how they contribute to cancer. We summarize recently developed high-throughput technologies to address these challenges. Finally, we outline future prospects for non-coding cancer genetics to help catalyze personalized cancer therapy.

Published in Frontiers in Genome Editing

ISSN: 2673-3439 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Biology (General): Genetics
Website: https://www.frontiersin.org/journals/genome-editing#

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Abstract

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