Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations

Yongchan Lee; Outi Haapanen; Anton Altmeyer; Werner Kühlbrandt; Vivek Sharma; Volker Zickermann

doi:10.1038/s41467-022-33640-y

Nature Communications (Oct 2022)

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations

Yongchan Lee,
Outi Haapanen,
Anton Altmeyer,
Werner Kühlbrandt,
Vivek Sharma,
Volker Zickermann

Affiliations

Yongchan Lee: Department of Structural Biology, Max Planck Institute of Biophysics
Outi Haapanen: Department of Physics, University of Helsinki
Anton Altmeyer: Institute of Biochemistry II, University Hospital, Goethe University
Werner Kühlbrandt: Department of Structural Biology, Max Planck Institute of Biophysics
Vivek Sharma: Department of Physics, University of Helsinki
Volker Zickermann: Institute of Biochemistry II, University Hospital, Goethe University

DOI: https://doi.org/10.1038/s41467-022-33640-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Many bacteria employ unique membrane transport systems to survive harsh environmental conditions. Here, authors determined the structure of a cation/proton antiporter at high resolution and studied its mechanism by computer simulations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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