Photodiagnosis and Photodynamic Therapy (Feb 2024)

Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases

  • Shanshan Ou,
  • Huanli Wang,
  • Weiyu Liu,
  • Huilan Zhu,
  • Wenjun Zhang,
  • Huaping Li,
  • Huiyan Deng

Journal volume & issue
Vol. 45
p. 103924

Abstract

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Significance: ALA-PDT effectively treats Vulvar lichen sclerosus et atrophicus (VLSA), but it requires multiple repetitions for satisfactory results. To enhance efficacy, we employed a combination of high-frequency electrocautery therapy and ALA-PDT in treating seven VLSA patients. Approach: Lesions and leukoplakia in the seven women with VLSA were removed using a high-frequency generator. PDT was administered after wound healing, and it was repeated six times. Follow-up assessments were carried out at 1, 3, and 6 months to evaluate the severity of pruritus and investigate lesion repigmentation. Results: Following the combined therapy, the disappearance of pruritus was observed in all patients, and normal color and thickness were restored to their skin. Two patients reported mild pruritus with a score of 2 one month after treatment, which persisted until the 6-month follow-up, while the remaining patients remained free from pruritus. No recurrence of skin lesions was observed in any of the patients. Conclusions: The combined therapy for the treatment of VLSA is found to be convenient, effective, and easily promotable.

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