Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Shreya Mitra; Jeffrey E. Montgomery; Matthew J. Kolar; Gang Li; Kang J. Jeong; Bo Peng; Gregory L. Verdine; Gordon B. Mills; Raymond E. Moellering

doi:10.1038/s41467-017-00888-8

Nature Communications (Sep 2017)

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Shreya Mitra,
Jeffrey E. Montgomery,
Matthew J. Kolar,
Gang Li,
Kang J. Jeong,
Bo Peng,
Gregory L. Verdine,
Gordon B. Mills,
Raymond E. Moellering

Affiliations

Shreya Mitra: Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
Jeffrey E. Montgomery: Department of Chemistry, The University of Chicago
Matthew J. Kolar: Department of Chemistry and Chemical Biology, Harvard University
Gang Li: Department of Chemistry, The University of Chicago
Kang J. Jeong: Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
Bo Peng: Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center
Gregory L. Verdine: Department of Chemistry and Chemical Biology, Harvard University
Gordon B. Mills: Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
Raymond E. Moellering: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/s41467-017-00888-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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