Incorporation of Ag NPs/palygorskite into chitosan/glycyrrhizic acid films as a potential antibacterial wound dressing

Qian Zhang; Hong Zhang; Aiping Hui; Yushen Lu; Aiqin Wang

Results in Materials (Jun 2023)

Incorporation of Ag NPs/palygorskite into chitosan/glycyrrhizic acid films as a potential antibacterial wound dressing

Qian Zhang,
Hong Zhang,
Aiping Hui,
Yushen Lu,
Aiqin Wang

Affiliations

Qian Zhang: Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China; Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, 730030, PR China
Hong Zhang: Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China
Aiping Hui: Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China
Yushen Lu: Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China
Aiqin Wang: Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China; Corresponding author. Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China

Journal volume & issue: Vol. 18
p. 100396

Abstract

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Chitosan/glycyrrhizic acid (CG) film has poor mechanical properties and antibacterial activity, which limits its practical application in wound dressing. In this study, Ag nanoparticles/palygorskite (Ag NPs/Pal) nanocomposites with different mass ratios were prepared by the metal salt pyrolysis and incorporated to synergistically improve the mechanical and antibacterial properties of CG films. The structural characteristics of CS/GA/Ag/Pal (CGAP) namocomposite films were characterized by SEM, ATR−FTIR and XRD. The effects of Ag NPs/Pal nanocomposites with different mass ratios on the physicochemical properties of the CGAP films were evaluated by systematic experiments. The CGAP nanocomposite films prepared by introducing Ag NPs/Pal nanocomposite with the mass ratio of AgNO3 to Pal of 0.5 had a uniform distribution of inorganic filler, good mechanical properties (tensile strength was 25.65 MPa and elongation at break was 63.71%) and excellent antibacterial activity (antibacterial effectiveness up to 100%), and preserved favorable swelling behavior (144.70%), acceptable light transmittance (T800 was 62.95%) and outstanding biocompatibility (hemolysis percentage was 1.69%). Overall, the above results demonstrate that the CGAP composite films are suitable for wound dressings in biomedical applications.

Published in Results in Materials

ISSN: 2590-048X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/results-in-materials

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