Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review

Yilma Hunde Gonfa; Fekade Beshah Tessema; Archana Bachheti; Nishant Rai; Mesfin Getachew Tadesse; A. Nasser Singab; Kundan Kumar Chaubey; Rakesh Kumar Bachheti

Current Research in Biotechnology (Jan 2023)

Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review

Yilma Hunde Gonfa,
Fekade Beshah Tessema,
Archana Bachheti,
Nishant Rai,
Mesfin Getachew Tadesse,
A. Nasser Singab,
Kundan Kumar Chaubey,
Rakesh Kumar Bachheti

Affiliations

Yilma Hunde Gonfa: Chemistry Department, Ambo University, P.O. Box: 19, Ambo, Ethiopia; Department of Industrial Chemistry, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, P.O. Box: 16417, Addis Ababa, Ethiopia
Fekade Beshah Tessema: Department of Industrial Chemistry, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, P.O. Box: 16417, Addis Ababa, Ethiopia; Chemistry Department, Woldia University, P.O. Box:400, Woldia, Ethiopia
Archana Bachheti: Department of Environment Science, Graphic Era (Deemed to be University), Dehradun, India; Corresponding authors.
Nishant Rai: Department of Biotechnology and Life Sciences, Graphic Era (Deemed to be University), Dehradun, India
Mesfin Getachew Tadesse: Department of Industrial Chemistry, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, P.O. Box: 16417, Addis Ababa, Ethiopia
A. Nasser Singab: Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt; Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt
Kundan Kumar Chaubey: Division of Research and Innovation, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, Uttarakhand-248007, India; School of Basic and Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh-281401, India
Rakesh Kumar Bachheti: Department of Industrial Chemistry, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, P.O. Box: 16417, Addis Ababa, Ethiopia; Department of Allied Sciences, Graphic Era Hill University, Society Area, Clement Town, Dehradun, 248002, India; Corresponding authors.

Journal volume & issue: Vol. 6
p. 100152

Abstract

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Plant-based phytochemicals are known for their potential sources of anti-inflammatory agents. Various studies reported the potential disease-healing efficiency of medicinal plants’ crude extracts, pure compounds, and their metal/metal oxide nanoparticles (M/MONPs) against inflammation. The purpose of this paper is to review the current research status of phytochemicals of medicinal plants and their nanoparticles as anti-inflammatory agents reported by various studies. Phytochemicals representing the class of flavonoids, terpenoids, polyphenols, saponins, tannins, alkaloids, anthraquinones, chemical constituents of essential oils, and some of their M/MONPs were reported from about 50 medicinal plants for the treatment of inflammatory diseases. The natural products of these plants demonstrated promising anti-inflammatory activities to treat skin, liver, cardiovascular, joint, gastrointestinal, neurological, and lung inflammation diseases. Besides, the mechanism of anti-inflammatory actions of phytochemicals and their M/MONPs agents are also summarized briefly. Various studies of phytochemistry, M/MONPs, and anti-inflammatory activities of phytochemicals from medicinal plants have developed novel, safe, and lesser side effects agents. Hence, this review may draw the attention of scholars more toward the investigation of natural products of medicinal plants and their nanoparticles in the treatment of different health disorders.

Published in Current Research in Biotechnology

ISSN: 2590-2628 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.journals.elsevier.com/current-research-in-biotechnology

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