Electronic Cigarette Use and the Risk of Cardiovascular Diseases

Jorge Espinoza-Derout; Jorge Espinoza-Derout; Xuesi M. Shao; Xuesi M. Shao; Candice J. Lao; Kamrul M. Hasan; Kamrul M. Hasan; Juan Carlos Rivera; Maria C. Jordan; Valentina Echeverria; Valentina Echeverria; Kenneth P. Roos; Amiya P. Sinha-Hikim; Amiya P. Sinha-Hikim; Theodore C. Friedman; Theodore C. Friedman; Theodore C. Friedman

doi:10.3389/fcvm.2022.879726

Frontiers in Cardiovascular Medicine (Apr 2022)

Electronic Cigarette Use and the Risk of Cardiovascular Diseases

Jorge Espinoza-Derout,
Jorge Espinoza-Derout,
Xuesi M. Shao,
Xuesi M. Shao,
Candice J. Lao,
Kamrul M. Hasan,
Kamrul M. Hasan,
Juan Carlos Rivera,
Maria C. Jordan,
Valentina Echeverria,
Valentina Echeverria,
Kenneth P. Roos,
Amiya P. Sinha-Hikim,
Amiya P. Sinha-Hikim,
Theodore C. Friedman,
Theodore C. Friedman,
Theodore C. Friedman

Affiliations

Jorge Espinoza-Derout: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Jorge Espinoza-Derout: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Xuesi M. Shao: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Xuesi M. Shao: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Candice J. Lao: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Kamrul M. Hasan: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Kamrul M. Hasan: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Juan Carlos Rivera: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Maria C. Jordan: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Valentina Echeverria: Research and Development Service, Bay Pines VA Healthcare System, Bay Pines, FL, United States
Valentina Echeverria: Laboratorio de Neurobiología, Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile
Kenneth P. Roos: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Amiya P. Sinha-Hikim: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Amiya P. Sinha-Hikim: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Theodore C. Friedman: Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Theodore C. Friedman: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Theodore C. Friedman: Friends Research Institute, Cerritos, CA, United States

DOI: https://doi.org/10.3389/fcvm.2022.879726
Journal volume & issue: Vol. 9

Abstract

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Electronic cigarettes or e-cigarettes are the most frequently used tobacco product among adolescents. Despite the widespread use of e-cigarettes and the known detrimental cardiac consequences of nicotine, the effects of e-cigarettes on the cardiovascular system are not well-known. Several in vitro and in vivo studies delineating the mechanisms of the impact of e-cigarettes on the cardiovascular system have been published. These include mechanisms associated with nicotine or other components of the aerosol or thermal degradation products of e-cigarettes. The increased hyperlipidemia, sympathetic dominance, endothelial dysfunction, DNA damage, and macrophage activation are prominent effects of e-cigarettes. Additionally, oxidative stress and inflammation are unifying mechanisms at many levels of the cardiovascular impairment induced by e-cigarette exposure. This review outlines the contribution of e-cigarettes in the development of cardiovascular diseases and their molecular underpinnings.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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