Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Chen-Ying Su; Chia-Chun Chen; Hsuan-Yu Chen; Chun-Pin Lin; Feng-Huei Lin; Hsu-Wei Fang

Journal of Dental Sciences (Jun 2019)

Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Chen-Ying Su,
Chia-Chun Chen,
Hsuan-Yu Chen,
Chun-Pin Lin,
Feng-Huei Lin,
Hsu-Wei Fang

Affiliations

Chen-Ying Su: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
Chia-Chun Chen: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
Hsuan-Yu Chen: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
Chun-Pin Lin: Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan
Feng-Huei Lin: Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institute, Miaoli County, Taiwan; Corresponding author. Institute of Biomedical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
Hsu-Wei Fang: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institute, Miaoli County, Taiwan; Corresponding author. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan.

Journal volume & issue: Vol. 14, no. 2
pp. 192 – 197

Abstract

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Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes. Keywords: Biomaterials, Mouthwash, Poly-gamma-glutamic acid (γ-PGA)

Published in Journal of Dental Sciences

ISSN: 1991-7902 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Dentistry
Website: http://www.journals.elsevier.com/journal-of-dental-sciences/

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