Nature Communications (Sep 2018)
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells
- Joseph C. Mudd,
- Kathleen Busman-Sahay,
- Sarah R. DiNapoli,
- Stephen Lai,
- Virginia Sheik,
- Andrea Lisco,
- Claire Deleage,
- Brian Richardson,
- David J. Palesch,
- Mirko Paiardini,
- Mark Cameron,
- Irini Sereti,
- R. Keith Reeves,
- Jacob D. Estes,
- Jason M. Brenchley
Affiliations
- Joseph C. Mudd
- Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kathleen Busman-Sahay
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc
- Sarah R. DiNapoli
- Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Stephen Lai
- Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Virginia Sheik
- Center for Drug Evaluation and Research, Food and Drug Administration
- Andrea Lisco
- Clinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Claire Deleage
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc
- Brian Richardson
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- David J. Palesch
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Mirko Paiardini
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Mark Cameron
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Irini Sereti
- Clinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- R. Keith Reeves
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Jacob D. Estes
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc
- Jason M. Brenchley
- Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-05528-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection.
