Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Xiaolong Fu; Peifeng Wan; Peipei Li; Jinpeng Wang; Siwei Guo; Yuan Zhang; Yachun An; Chao Ye; Ziyi Liu; Jiangang Gao; Jianming Yang; Jiangang Fan; Renjie Chai; Renjie Chai; Renjie Chai; Renjie Chai

doi:10.3389/fncel.2021.692762

Frontiers in Cellular Neuroscience (Jun 2021)

Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Xiaolong Fu,
Peifeng Wan,
Peipei Li,
Jinpeng Wang,
Siwei Guo,
Yuan Zhang,
Yachun An,
Chao Ye,
Ziyi Liu,
Jiangang Gao,
Jianming Yang,
Jiangang Fan,
Renjie Chai,
Renjie Chai,
Renjie Chai,
Renjie Chai

Affiliations

Xiaolong Fu: State Key Laboratory of Bioelectronics, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Peifeng Wan: School of Life Science, Shandong University, Qingdao, China
Peipei Li: Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Jinpeng Wang: The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Science, Shandong Normal University, Jinan, China
Siwei Guo: School of Life Science, Shandong University, Qingdao, China
Yuan Zhang: Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yachun An: School of Life Science, Shandong University, Qingdao, China
Chao Ye: School of Life Science, Shandong University, Qingdao, China
Ziyi Liu: School of Life Science, Shandong University, Qingdao, China
Jiangang Gao: School of Life Science, Shandong University, Qingdao, China
Jianming Yang: Second Hospital of Anhui Medical University, Hefei, China
Jiangang Fan: Department of Otolaryngology Head and Neck Surgery, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu, China
Renjie Chai: State Key Laboratory of Bioelectronics, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China
Renjie Chai: Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China
Renjie Chai: Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
Renjie Chai: Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China

DOI: https://doi.org/10.3389/fncel.2021.692762
Journal volume & issue: Vol. 15

Abstract

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Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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