Refractory primary mediastinal malignant germ cell tumor with multiple systemic metastases: A rare case report

Abstract

The incidence of extra-gonadal germ cell tumor is low. There are few reports about liver metastasis and multiple systemic metastasis of mediastinal germ cell tumor. Here, we report a case of a 42-year-old young man with mediastinal mass discovered by computed tomography, which was finally confirmed as mediastinal germ cell tumor after many pathological biopsies. After radiotherapy and chemotherapy, the mediastinal mass was stable, but a new mass appeared in the liver. Mediastinal mass remained stable after modification of treatment regimen, but multiple metastases were found throughout the body. He finally died after 8 months of treatment because of his poor health.

Keywords

• Extra-gonadal germ cell tumors
• Primary mediastinal germ cell tumor
• Liver metastasis
• Non-seminoma germ cell tumor