Molecules (May 2024)

Kallopterolides A–I, a New Subclass of <i>seco</i>-Diterpenes Isolated from the Southwestern Caribbean Sea Plume <i>Antillogorgia kallos</i>

  • Jeffrey Marrero,
  • Luis A. Amador,
  • Ivan M. Novitskiy,
  • Andrei G. Kutateladze,
  • Abimael D. Rodríguez

DOI
https://doi.org/10.3390/molecules29112493
Journal volume & issue
Vol. 29, no. 11
p. 2493

Abstract

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Kallopterolides A–I (1–9), a family of nine diterpenoids possessing either a cleaved pseudopterane or a severed cembrane skeleton, along with several known compounds were isolated from the Caribbean Sea plume Antillogorgia kallos. The structures and relative configurations of 1–9 were characterized by analysis of HR-MS, IR, UV, and NMR spectroscopic data in addition to computational methods and side-by-side comparisons with published NMR data of related congeners. An investigation was conducted as to the potential of the kallopterolides as plausible in vitro anti-inflammatory, antiprotozoal, and antituberculosis agents.

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