Nature Communications (Jul 2017)
PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
Abstract
Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.