Nature Communications (Jul 2017)

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints

  • Saw-See Hong,
  • Hubert Marotte,
  • Guillaume Courbon,
  • Gary S. Firestein,
  • Pierre Boulanger,
  • Pierre Miossec

DOI
https://doi.org/10.1038/s41467-017-00142-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.