Frontiers in Chemistry (Jan 2022)

Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

  • Latifah A. Alshabanah,
  • Laila A. Al-Mutabagani,
  • Sobhi M. Gomha,
  • Sobhi M. Gomha,
  • Hoda A. Ahmed,
  • Hoda A. Ahmed

DOI
https://doi.org/10.3389/fchem.2021.762248
Journal volume & issue
Vol. 9

Abstract

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A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.

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