Nature Communications (Jun 2022)
ZFP281-BRCA2 prevents R-loop accumulation during DNA replication
- Yan Wang,
- Binbin Ma,
- Xiaoxu Liu,
- Ge Gao,
- Zhuanzhuan Che,
- Menghan Fan,
- Siyan Meng,
- Xiru Zhao,
- Rio Sugimura,
- Hua Cao,
- Zhongjun Zhou,
- Jing Xie,
- Chengqi Lin,
- Zhuojuan Luo
Affiliations
- Yan Wang
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Binbin Ma
- Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University
- Xiaoxu Liu
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Ge Gao
- School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
- Zhuanzhuan Che
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Menghan Fan
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Siyan Meng
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Xiru Zhao
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- Rio Sugimura
- School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
- Hua Cao
- Key Laboratory of Technical Evaluation of Fertility Regulation of Non-human primate, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University
- Zhongjun Zhou
- School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
- Jing Xie
- Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University
- Chengqi Lin
- Key Laboratory of Technical Evaluation of Fertility Regulation of Non-human primate, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University
- Zhuojuan Luo
- Jiangsu Provincial Key Laboratory of Critical Care Medicine, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University
- DOI
- https://doi.org/10.1038/s41467-022-31211-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
R-loops are prevalent in mammalian genomes and involved in many fundamental cellular processes. Here, Wang et al. report that ZFP281 cooperates with BRCA2 in preventing R-loop accumulation to facilitate DNA replication in embryonic stem cells.
