The Emerging Role of STING in Insect Innate Immune Responses and Pathogen Evasion Strategies

Qiuning Liu; Qiuning Liu; Qiuning Liu; Saima Kausar; Yingyu Tang; Yingyu Tang; Wuren Huang; Boping Tang; Muhammad Nadeem Abbas; Lishang Dai

doi:10.3389/fimmu.2022.874605

Frontiers in Immunology (May 2022)

The Emerging Role of STING in Insect Innate Immune Responses and Pathogen Evasion Strategies

Qiuning Liu,
Qiuning Liu,
Qiuning Liu,
Saima Kausar,
Yingyu Tang,
Yingyu Tang,
Wuren Huang,
Boping Tang,
Muhammad Nadeem Abbas,
Lishang Dai

Affiliations

Qiuning Liu: Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands, Yancheng Teachers University, Yancheng, China
Qiuning Liu: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
Qiuning Liu: Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China
Saima Kausar: State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
Yingyu Tang: Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands, Yancheng Teachers University, Yancheng, China
Yingyu Tang: Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China
Wuren Huang: Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China
Boping Tang: Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands, Yancheng Teachers University, Yancheng, China
Muhammad Nadeem Abbas: State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
Lishang Dai: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

DOI: https://doi.org/10.3389/fimmu.2022.874605
Journal volume & issue: Vol. 13

Abstract

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Emerging evidence reveals that the stimulator of the interferon genes (STING) signaling pathway in insects and other animal cells helps them to sense and effectively respond to infection caused by numerous types of microbial pathogens. Recent studies have shown that genomic material from microbial pathogens induces the STING signaling pathway for the production of immune factors to attenuate infection. In contrast, microbial pathogens are equipped with various factors that assist them in evading the STING signaling cascade. Here we discuss the STING signaling pathway different animal groups compared to human and then focus on its crucial biological roles and application in the microbial infection of insects. In addition, we examine the negative and positive modulators of the STING signaling cascade. Finally, we describe the microbial pathogen strategies to evade this signaling cascade for successful invasion.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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