Nature Communications (Dec 2017)

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

  • Karen S. Conrad,
  • Ting-Wen Cheng,
  • Daniel Ysselstein,
  • Saskia Heybrock,
  • Lise R. Hoth,
  • Boris A. Chrunyk,
  • Christopher W. am Ende,
  • Dimitri Krainc,
  • Michael Schwake,
  • Paul Saftig,
  • Shenping Liu,
  • Xiayang Qiu,
  • Michael D. Ehlers

DOI
https://doi.org/10.1038/s41467-017-02044-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.