Nature Communications (Dec 2017)

PEPD is a pivotal regulator of p53 tumor suppressor

  • Lu Yang,
  • Yun Li,
  • Arup Bhattacharya,
  • Yuesheng Zhang

DOI
https://doi.org/10.1038/s41467-017-02097-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.