Identification and characterization of a novel botulinum neurotoxin

Sicai Zhang; Geoffrey Masuyer; Jie Zhang; Yi Shen; Daniel Lundin; Linda Henriksson; Shin-Ichiro Miyashita; Markel Martínez-Carranza; Min Dong; Pål Stenmark

doi:10.1038/ncomms14130

Nature Communications (Aug 2017)

Identification and characterization of a novel botulinum neurotoxin

Sicai Zhang,
Geoffrey Masuyer,
Jie Zhang,
Yi Shen,
Daniel Lundin,
Linda Henriksson,
Shin-Ichiro Miyashita,
Markel Martínez-Carranza,
Min Dong,
Pål Stenmark

Affiliations

Sicai Zhang: Department of Urology, Department of Microbiology and Immunobiology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School
Geoffrey Masuyer: Department of Biochemistry and Biophysics, Stockholm University
Jie Zhang: Department of Urology, Department of Microbiology and Immunobiology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School
Yi Shen: Department of Urology, Department of Microbiology and Immunobiology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School
Daniel Lundin: Department of Biochemistry and Biophysics, Stockholm University
Linda Henriksson: Department of Biochemistry and Biophysics, Stockholm University
Shin-Ichiro Miyashita: Department of Urology, Department of Microbiology and Immunobiology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School
Markel Martínez-Carranza: Department of Biochemistry and Biophysics, Stockholm University
Min Dong: Department of Urology, Department of Microbiology and Immunobiology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School
Pål Stenmark: Department of Biochemistry and Biophysics, Stockholm University

DOI: https://doi.org/10.1038/ncomms14130
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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There are seven well-established types of Botulinum neurotoxins (BoNTs). Here the authors report the identification and characterization of a new type of BoNT—BoNT/X—which cleaves a different site on canonical BoNTs substrates and targets SNARE family members not cleaved by known BoNTs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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