Nature Communications (Jan 2018)

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

  • Alba Duch,
  • Berta Canal,
  • Sonia I. Barroso,
  • María García-Rubio,
  • Gerhard Seisenbacher,
  • Andrés Aguilera,
  • Eulàlia de Nadal,
  • Francesc Posas

DOI
https://doi.org/10.1038/s41467-017-02756-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replication during unscheduled transcription events.