Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.
Chin-Soon Phan,
Shean-Yeaw Ng,
Eun-A Kim,
You-Jin Jeon,
Kishneth Palaniveloo,
Charles Santhanaraju Vairappan
Affiliations
Chin-Soon Phan
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia
Shean-Yeaw Ng
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia
Eun-A Kim
Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea
You-Jin Jeon
Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea
Kishneth Palaniveloo
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia
Charles Santhanaraju Vairappan
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia
Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.
