A Review on Synthesis of Quinoline Analogs as Antimalarial, Antibacterial and Anticancer agents

Abstract

Numerous natural products possessing quinoline moiety exhibit interesting biological and pharmacological properties, such as antimalarial, antibacterial, antiasthmatic, antihypertensive, anti-inflammatory, immunosuppressive, antileishmanial, and anticancer activity. Surprising, quinoline scaffold has been used to synthesize antimalarial, antibacterial and anticancer drugs. This article provides update on the latest development in synthesis and biological evaluation of antimalarial, antibacterial and anticancer quinoline analogs. The new synthetic methodologies and the biological activities of the new quinoline analogs in the three areas were focused. Key words: antimalarial, antibacterial, anticancer and quinoline