Cardiovascular Innovations and Applications (Aug 2016)

Inflammasomes and Atherosclerosis

  • S. Vallurupalli,
  • Yao Dai,
  • J. L. Mehta

DOI
https://doi.org/10.15212/cvia.2016.0028
Journal volume & issue
Vol. 1, no. 4
pp. 443 – 450

Abstract

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Inflammation plays an important role in atherosclerosis. Inflammasomes play a crucial role in innate immunity, which mediates the body’s response to various pathogens. Of the different types of inflammasomes, NLRP3 has been implicated in atherosclerosis through the production of proinflammatory cytokines, IL-1β and IL-18. This review describes the role of the NLRP3 inflammasome in atherosclerosis and discusses potential therapeutic targets in the inflammasome pathway.