JACC: Advances (Apr 2025)
Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair
- Kenichi Shibata, PT,
- Masanori Yamamoto, MD,
- Ai Kagase, MD,
- Takahiro Tokuda, MD,
- Hiroshi Tsunamoto, MD,
- Testuro Shimura, MD,
- Azusa Kurita, MD,
- Ryo Yamaguchi, MD,
- Mike Saji, MD,
- Masahiko Asami, MD,
- Yusuke Enta, MD,
- Masaki Nakashima, MD,
- Shinichi Shirai, MD,
- Masaki Izumo, MD,
- Shingo Mizuno, MD,
- Yusuke Watanabe, MD,
- Makoto Amaki, MD,
- Kazuhisa Kodama, MD,
- Junichi Yamaguchi, MD,
- Toru Naganuma, MD,
- Hiroki Bota, MD,
- Yohei Ohno, MD,
- Masahiro Yamawaki, MD,
- Daisuke Hachinohe, MD,
- Hiroshi Ueno, MD,
- Kazuki Mizutani, MD,
- Toshiaki Otsuka, MD,
- Shunsuke Kubo, MD,
- Kentaro Hayashida, MD
Affiliations
- Kenichi Shibata, PT
- Department of Rehabilitation, Nagoya Heart Center, Nagoya, Japan; Dr Kenichi Shibata, Department of Cardiology, Nagoya Heart Center, 1-1-14 Sunadabashi, Higashi-ku, Nagoya Aichi 461-0045, Japan.
- Masanori Yamamoto, MD
- Department of Cardiology, Nagoya Heart Center, Nagoya, Japan; Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan; Department of Cardiology, Gifu Heart Center, Gifu, Japan; Address for correspondence: Dr Masanori Yamamoto, Department of Cardiology, Nagoya Heart Center, 1-1-14 Sunadabashi, Higashi-ku, Nagoya Aichi 461-0045, Japan.
- Ai Kagase, MD
- Department of Cardiology, Nagoya Heart Center, Nagoya, Japan
- Takahiro Tokuda, MD
- Department of Cardiology, Nagoya Heart Center, Nagoya, Japan
- Hiroshi Tsunamoto, MD
- Department of Cardiology, Nagoya Heart Center, Nagoya, Japan
- Testuro Shimura, MD
- Department of Cardiology, Gifu Heart Center, Gifu, Japan
- Azusa Kurita, MD
- Department of Cardiology, Gifu Heart Center, Gifu, Japan
- Ryo Yamaguchi, MD
- Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan
- Mike Saji, MD
- Department of Cardiology, Sakakibara Heart Institute, Fuchu, Japan
- Masahiko Asami, MD
- Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan
- Yusuke Enta, MD
- Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan
- Masaki Nakashima, MD
- Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan
- Shinichi Shirai, MD
- Division of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan
- Masaki Izumo, MD
- Division of Cardiology, St. Marianna University School of Medicine Hospital, Kawasaki, Japan
- Shingo Mizuno, MD
- Department of Cardiology, Shonan Kamakura General Hospital, Kanagawa, Japan
- Yusuke Watanabe, MD
- Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan
- Makoto Amaki, MD
- Department of Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
- Kazuhisa Kodama, MD
- Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan
- Junichi Yamaguchi, MD
- Department of Cardiology, Tokyo Woman’s Medical University, Tokyo, Japan
- Toru Naganuma, MD
- Department of Cardiology, New Tokyo Hospital, Chiba, Japan
- Hiroki Bota, MD
- Department of Cardiology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan
- Yohei Ohno, MD
- Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
- Masahiro Yamawaki, MD
- Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan
- Daisuke Hachinohe, MD
- Department of Cardiology, Sapporo Heart Center, Sapporo Cardio Vascular Clinic, Sapporo, Japan
- Hiroshi Ueno, MD
- Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan
- Kazuki Mizutani, MD
- Division of Cardiology, Department of Medicine, Kinki University Faculty of Medicine, Osaka, Japan
- Toshiaki Otsuka, MD
- Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
- Shunsuke Kubo, MD
- Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan
- Kentaro Hayashida, MD
- Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
- Journal volume & issue
-
Vol. 4,
no. 4
p. 101631
Abstract
Background: Transcatheter edge-to-edge repair (TEER) is used to treat patients with mitral regurgitation (MR). The Geriatric Nutritional Risk Index (GNRI) is a well-known nutritional marker that predicts mortality risk. Objectives: The objectives of this study were to elucidate the clinical association between the degree of GNRI and different etiologies of MR and to clarify the patient samples for whom GNRI is more relevant to clinical outcomes following TEER. Methods: Data from 3,554 patients with MR who underwent TEER were analyzed using a Japanese multicenter registry. The patients were classified into 4 groups: GNRI 98. Procedural and clinical outcomes were compared between GNRI groups. Short- and long-term all-cause mortality were explored using Cox regression analysis. Results: Among the 3,554 patients, the median GNRI was 92.3. The mean follow-up period was 586.8 ± 436.5 days; 806 patients died during the follow-up period. Thirty-day mortality occurred in 51 patients (1.4%), and the GNRI 98 as the reference. Conclusions: Regardless of MR etiology, GNRI is a useful predictor of short- and long-term mortality in patients undergoing TEER. Although TEER is effective for MR patients in malnourished states, further studies focused on the value of identifying and addressing malnutrition in this population are needed.
