Antibiotics (Feb 2014)

Experimental Simulation of the Effects of an Initial Antibiotic Treatment on a Subsequent Treatment after Initial Therapy Failure

  • Yanfang Feng,
  • Nadine Händel,
  • Marnix H. P. de Groot,
  • Stanley Brul,
  • Constance Schultsz,
  • Benno H. ter Kuile

DOI
https://doi.org/10.3390/antibiotics3010049
Journal volume & issue
Vol. 3, no. 1
pp. 49 – 63

Abstract

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Therapy failure of empirical antibiotic treatments prescribed by primary care physicians occurs commonly. The effect of such a treatment on the susceptibility to second line antimicrobial drugs is unknown. Resistance to amoxicillin was rapidly induced or selected in E. coli at concentrations expected in the patient’s body. Strains with reduced susceptibility outcompeted the wild-type whenever antibiotics were present, even in low concentrations that did not affect the growth rates of both strains. Exposure of E. coli to amoxicillin caused moderate resistance to cefotaxime. The combined evidence suggests that initial treatment by amoxicillin has a negative effect on subsequent therapy with beta-lactam antibiotics.

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