Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Claudia M. Rival; Wenhao Xu; Laura S. Shankman; Sho Morioka; Sanja Arandjelovic; Chang Sup Lee; Karen M. Wheeler; Ryan P. Smith; Lisa B. Haney; Brant E. Isakson; Scott Purcell; Jeffrey J. Lysiak; Kodi S. Ravichandran

doi:10.1038/s41467-019-12406-z

Nature Communications (Oct 2019)

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Claudia M. Rival,
Wenhao Xu,
Laura S. Shankman,
Sho Morioka,
Sanja Arandjelovic,
Chang Sup Lee,
Karen M. Wheeler,
Ryan P. Smith,
Lisa B. Haney,
Brant E. Isakson,
Scott Purcell,
Jeffrey J. Lysiak,
Kodi S. Ravichandran

Affiliations

Claudia M. Rival: The Center for Cell Clearance, School of Medicine, University of Virginia
Wenhao Xu: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia
Laura S. Shankman: The Center for Cell Clearance, School of Medicine, University of Virginia
Sho Morioka: The Center for Cell Clearance, School of Medicine, University of Virginia
Sanja Arandjelovic: The Center for Cell Clearance, School of Medicine, University of Virginia
Chang Sup Lee: The Center for Cell Clearance, School of Medicine, University of Virginia
Karen M. Wheeler: Department of Urology, School of Medicine, University of Virginia
Ryan P. Smith: Department of Urology, School of Medicine, University of Virginia
Lisa B. Haney: The Center for Cell Clearance, School of Medicine, University of Virginia
Brant E. Isakson: Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia
Scott Purcell: Reproductive Medicine and Surgery Center of Virginia
Jeffrey J. Lysiak: The Center for Cell Clearance, School of Medicine, University of Virginia
Kodi S. Ravichandran: The Center for Cell Clearance, School of Medicine, University of Virginia

DOI: https://doi.org/10.1038/s41467-019-12406-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is required for sperm-egg fusion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal