Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives

Abstract

A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. The structures were established on the basis of their IR, 1H-NMR, 13C-NMR, ESI-MS data and also the compound with 3f were crystallized and analysed by single crystal X-ray diffraction studies.

Keywords

• Pyrimido[1
• 2-a]benzimidazolone
• Sulfonamide
• Anti-tuberculosis
• Single crystal x-ray diffraction
• Ionic liquid