Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Voice Intensity

Sofie Lundgren; Thomas Saeys; Fredrik Karlsson; Katarina Olofsson; Patric Blomstedt; Jan Linder; Erik Nordh; Hamayun Zafar; Jan van Doorn

doi:10.4061/2011/658956

Parkinson's Disease (Jan 2011)

Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Voice Intensity

Sofie Lundgren,
Thomas Saeys,
Fredrik Karlsson,
Katarina Olofsson,
Patric Blomstedt,
Jan Linder,
Erik Nordh,
Hamayun Zafar,
Jan van Doorn

Affiliations

Sofie Lundgren: Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden
Thomas Saeys: Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden
Fredrik Karlsson: Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden
Katarina Olofsson: Division of Otorhinolaryngology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden
Patric Blomstedt: Division of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, Sweden
Jan Linder: Division of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, Sweden
Erik Nordh: Division of Clinical Neuroscience, Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-90185 Umeå, Sweden
Hamayun Zafar: Rehabilitation Research Chair, King Saud University, Riyadh 11433, Saudi Arabia
Jan van Doorn: Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden

DOI: https://doi.org/10.4061/2011/658956
Journal volume & issue: Vol. 2011

Abstract

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Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently. Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated. The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients. Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation. For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0) dB contra 72.1 (2.2) dB (𝑃=.002) for STN-DBS, and 71.6 (4.1) dB contra 72.8 (3.4) dB (𝑃=.03) for cZi-DBS, with significant interaction (𝑃<.001). Intensity decay showed no significant changes. The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.

Published in Parkinson's Disease

ISSN: 2090-8083 (Print); 2042-0080 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://onlinelibrary.wiley.com/journal/1618

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