Проблемы особо опасных инфекций (Jun 2013)
Studies of Anti-Viral Activity of Chemically Synthesized Compounds against Orthopoxviruses <I>in vitro</I>
- A. S. Kabanov,
- Al. A. Sergeev,
- L. E. Bulychev,
- N. I. Bormotov,
- L. N. Shishkina,
- Ar. A. Sergeev,
- S. A. Bodnev,
- M. O. Skarnovich,
- A. R. Shevtsov,
- B. A. Selivanov,
- A. Ya. Tikhonov,
- A. P. Agafonov,
- A. N. Sergeev
Affiliations
- A. S. Kabanov
- State Research Centre of Virology and Biotechnology “Vector”
- Al. A. Sergeev
- State Research Centre of Virology and Biotechnology “Vector”
- L. E. Bulychev
- State Research Centre of Virology and Biotechnology “Vector”
- N. I. Bormotov
- State Research Centre of Virology and Biotechnology “Vector”
- L. N. Shishkina
- State Research Centre of Virology and Biotechnology “Vector”
- Ar. A. Sergeev
- State Research Centre of Virology and Biotechnology “Vector”
- S. A. Bodnev
- State Research Centre of Virology and Biotechnology “Vector”
- M. O. Skarnovich
- State Research Centre of Virology and Biotechnology “Vector”
- A. R. Shevtsov
- State Research Centre of Virology and Biotechnology “Vector”
- B. A. Selivanov
- Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry, RAS SB
- A. Ya. Tikhonov
- Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry, RAS SB
- A. P. Agafonov
- State Research Centre of Virology and Biotechnology “Vector”
- A. N. Sergeev
- State Research Centre of Virology and Biotechnology “Vector”
- DOI
- https://doi.org/10.21055/0370-1069-2013-2-54-59
- Journal volume & issue
-
Vol. 0,
no. 2
pp. 54 – 59
Abstract
for ST-246 and NIOC-14 is within the range of 0,001-0,004 µg/ml, and IS for both of them is > 100000. In addition, ST-246 and NIOC-14 chemical compound efficacy, concentrated up to 0,0125; 0,025 and 0,05 µg/ml, in accordance with prophylactic charts describing an impact on ectromelia virus (EV) infectivity in vitro, is consequently 0,6; 3 and 1 lg higher than in case of compound application after an hour of Vero cells infection with EV.
Keywords
- ортопоксвирусы
- вирус оспы обезьян
- вирус натуральной оспы
- культура клеток vero
- токсичность
- противовирусная активность
- конденсированные производные пирролидин-2
- 5-диона
- orthopoxviruses
- monkeypox virus
- variola virus
- vero cell culture
- toxicity
- anti-viral activity
- condensed derivatives of pyrrolidine-25-dion
