The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

Abstract

Bacteria produce small iron-binding molecules called siderophores, which are recognised by outer-membrane transporters. Here, the authors show that a Pseudomonas transporter recognises the siderophore enterobactin using extracellular loops distant from the pore, and propose that there is a second binding site deeper inside the structure.