Frontiers in Immunology (Sep 2021)
Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report
- Karen R. Sherwood,
- Karen R. Sherwood,
- David D. M. Nicholl,
- Franz Fenninger,
- Vivian Wu,
- Paaksum Wong,
- Vince Benedicto,
- Davide P. Cina,
- Meng Wang,
- Taylor D. Pobran,
- Mari L. De Marco,
- Mari L. De Marco,
- Anna Citlali Márquez,
- Agatha N. Jassem,
- Agatha N. Jassem,
- Inna Sekirov,
- Inna Sekirov,
- Muhammad G. Morshed,
- Muhammad G. Morshed,
- Mohammad Bardi,
- Mohammad Bardi,
- Mypinder Sekhon,
- Paul Keown,
- Paul Keown,
- Matthew Kadatz,
- Matthew Kadatz,
- James H. Lan,
- James H. Lan,
- James H. Lan
Affiliations
- Karen R. Sherwood
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Karen R. Sherwood
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- David D. M. Nicholl
- Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
- Franz Fenninger
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Vivian Wu
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Paaksum Wong
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Vince Benedicto
- British Columbia Provincial Immunology Laboratory, University of British Columbia, Vancouver, BC, Canada
- Davide P. Cina
- Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
- Meng Wang
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Taylor D. Pobran
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Mari L. De Marco
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Mari L. De Marco
- Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, Canada
- Anna Citlali Márquez
- British Columbia Center for Disease Control Public Health Laboratory, Provincial Health Services Authority, Vancouver, BC, Canada
- Agatha N. Jassem
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Agatha N. Jassem
- British Columbia Center for Disease Control Public Health Laboratory, Provincial Health Services Authority, Vancouver, BC, Canada
- Inna Sekirov
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Inna Sekirov
- British Columbia Center for Disease Control Public Health Laboratory, Provincial Health Services Authority, Vancouver, BC, Canada
- Muhammad G. Morshed
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Muhammad G. Morshed
- British Columbia Center for Disease Control Public Health Laboratory, Provincial Health Services Authority, Vancouver, BC, Canada
- Mohammad Bardi
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Mohammad Bardi
- Division of Rheumatology, University of British Columbia, Vancouver, BC, Canada
- Mypinder Sekhon
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Paul Keown
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Paul Keown
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- Matthew Kadatz
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- Matthew Kadatz
- Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
- James H. Lan
- Department of Medicine, University of British Columbia, Vancouver, BC, Canada
- James H. Lan
- Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
- James H. Lan
- Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
- DOI
- https://doi.org/10.3389/fimmu.2021.753558
- Journal volume & issue
-
Vol. 12
Abstract
To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.
Keywords
