Nature Communications (Jan 2019)
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity
- Michela Capello,
- Jody V. Vykoukal,
- Hiroyuki Katayama,
- Leonidas E. Bantis,
- Hong Wang,
- Deepali L. Kundnani,
- Clemente Aguilar-Bonavides,
- Mitzi Aguilar,
- Satyendra C. Tripathi,
- Dilsher S. Dhillon,
- Amin A. Momin,
- Haley Peters,
- Matthew H. Katz,
- Hector Alvarez,
- Vincent Bernard,
- Sammy Ferri-Borgogno,
- Randall Brand,
- Douglas G. Adler,
- Matthew A. Firpo,
- Sean J. Mulvihill,
- Jeffrey J. Molldrem,
- Ziding Feng,
- Ayumu Taguchi,
- Anirban Maitra,
- Samir M. Hanash
Affiliations
- Michela Capello
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Jody V. Vykoukal
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Hiroyuki Katayama
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Leonidas E. Bantis
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Hong Wang
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Deepali L. Kundnani
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Clemente Aguilar-Bonavides
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Mitzi Aguilar
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Satyendra C. Tripathi
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Dilsher S. Dhillon
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Amin A. Momin
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Haley Peters
- Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center
- Matthew H. Katz
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Hector Alvarez
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Vincent Bernard
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Sammy Ferri-Borgogno
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Randall Brand
- Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh
- Douglas G. Adler
- Department of Internal Medicine, University of Utah School of Medicine
- Matthew A. Firpo
- Department of Surgery, University of Utah School of Medicine
- Sean J. Mulvihill
- Department of Surgery, University of Utah School of Medicine
- Jeffrey J. Molldrem
- Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center
- Ziding Feng
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Ayumu Taguchi
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Anirban Maitra
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Samir M. Hanash
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-08109-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.
