eLife (Jul 2017)
Building bridges between cellular and molecular structural biology
- Ardan Patwardhan,
- Robert Brandt,
- Sarah J Butcher,
- Lucy Collinson,
- David Gault,
- Kay Grünewald,
- Corey Hecksel,
- Juha T Huiskonen,
- Andrii Iudin,
- Martin L Jones,
- Paul K Korir,
- Abraham J Koster,
- Ingvar Lagerstedt,
- Catherine L Lawson,
- David Mastronarde,
- Matthew McCormick,
- Helen Parkinson,
- Peter B Rosenthal,
- Stephan Saalfeld,
- Helen R Saibil,
- Sirarat Sarntivijai,
- Irene Solanes Valero,
- Sriram Subramaniam,
- Jason R Swedlow,
- Ilinca Tudose,
- Martyn Winn,
- Gerard J Kleywegt
Affiliations
- Ardan Patwardhan
- ORCiD
- Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Robert Brandt
- Visualization Sciences Group, FEI, Mérignac, France
- Sarah J Butcher
- Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki, Finland
- Lucy Collinson
- Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom
- David Gault
- Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom
- Kay Grünewald
- Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Corey Hecksel
- National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States
- Juha T Huiskonen
- Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Andrii Iudin
- Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Martin L Jones
- ORCiD
- Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom
- Paul K Korir
- Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Abraham J Koster
- Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
- Ingvar Lagerstedt
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Catherine L Lawson
- Center for Integrative Proteomics Research and the Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, United States
- David Mastronarde
- Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, United States
- Matthew McCormick
- Kitware, Inc., Carrboro, United States
- Helen Parkinson
- Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Peter B Rosenthal
- Structural Biology of Cells and Viruses, Francis Crick Institute, London, United Kingdom
- Stephan Saalfeld
- ORCiD
- Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
- Helen R Saibil
- Institute of Structural and Molecular Biology, Department of Crystallography, Birkbeck College, London, United Kingdom
- Sirarat Sarntivijai
- Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Irene Solanes Valero
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Sriram Subramaniam
- Laboratory for Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States
- Jason R Swedlow
- Centre for Gene Regulation and Expression and the Division of Computational Biology, University of Dundee, Dundee, United Kingdom
- Ilinca Tudose
- Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- Martyn Winn
- Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot, United Kingdom
- Gerard J Kleywegt
- Molecular and Cellular Structure Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom
- DOI
- https://doi.org/10.7554/eLife.25835
- Journal volume & issue
-
Vol. 6
Abstract
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.
Keywords
