Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation

• Johann Greil,
• Maria V. Verga-Falzacappa,
• Nicole E. Echner,
• Wolfgang Behnisch,
• Obul R. Bandapalli,
• Paulina Pechanska,
• Stephan Immenschuh,
• Vijith Vijayan,
• Jozsef Balla,
• Hirokatsu Tsukahara,
• Marion Schneider,
• Gritta Janka,
• Maren Claus,
• Thomas Longerich,
• Martina U. Muckenthaler,
• Andreas E. Kulozik

Affiliations

Johann Greil

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Maria V. Verga-Falzacappa

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Nicole E. Echner

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Wolfgang Behnisch

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Obul R. Bandapalli

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Paulina Pechanska

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Stephan Immenschuh

Institute for Transfusion Medicine, Hannover Medical School, Germany

Vijith Vijayan

Institute for Transfusion Medicine, Hannover Medical School, Germany

Jozsef Balla

Department. of Nephrology, Medical and Health Science Center, University of Debrecen, Hungary;MTA-DE Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences Debrecen, Hungary

Hirokatsu Tsukahara

Department of Pediatrics, Okayama University Graduate School of Medicine, Japan

Marion Schneider

Section of Experimental Anesthesiology, University of Ulm, Germany

Gritta Janka

Department of Hematology and Oncology, Children’s Hospital, University of Hamburg, Germany

Maren Claus

Institute for Immunology, University Heidelberg, Germany

Thomas Longerich

Institute of Pathology, University of Heidelberg, Germany

Martina U. Muckenthaler

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany

Andreas E. Kulozik

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany