Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic <i>Caenorhabditis elegans</i>

Abstract

AbstractAmyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused by aberrant activity of a set of proteins including TDP-43 and UBIQUILIN-2 (UBQLN2). UBQLN2Caenorhabditis elegansC. eleganstdp-1