The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Fabrizio Michetti; Gabriele Di Sante; Maria Elisabetta Clementi; Federica Valeriani; Martina Mandarano; Francesco Ria; Rosa Di Liddo; Mario Rende; Vincenzo Romano Spica

doi:10.3390/ijms25020776

International Journal of Molecular Sciences (Jan 2024)

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Fabrizio Michetti,
Gabriele Di Sante,
Maria Elisabetta Clementi,
Federica Valeriani,
Martina Mandarano,
Francesco Ria,
Rosa Di Liddo,
Mario Rende,
Vincenzo Romano Spica

Affiliations

Fabrizio Michetti: Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” SCITEC-CNR, L.go F. Vito 1, 00168 Rome, Italy
Gabriele Di Sante: Department of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, 06132 Perugia, Italy
Maria Elisabetta Clementi: Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” SCITEC-CNR, L.go F. Vito 1, 00168 Rome, Italy
Federica Valeriani: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Martina Mandarano: Department of Medicine and Surgery, Section of Anatomic Pathology and Histology, Medical School, University of Perugia, 06132 Perugia, Italy
Francesco Ria: Department of Translational Medicine and Surgery, Section of General Pathology, Catholic University of the Sacred Heart, 00168 Rome, Italy
Rosa Di Liddo: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy
Mario Rende: Department of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, 06132 Perugia, Italy
Vincenzo Romano Spica: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy

DOI: https://doi.org/10.3390/ijms25020776
Journal volume & issue: Vol. 25, no. 2
p. 776

Abstract

Read online

The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

About the journal

Abstract

Keywords