Nature Communications (Jun 2018)

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

  • Zhen Liu,
  • Zongyang Lu,
  • Guang Yang,
  • Shisheng Huang,
  • Guanglei Li,
  • Songjie Feng,
  • Yajing Liu,
  • Jianan Li,
  • Wenxia Yu,
  • Yu Zhang,
  • Jia Chen,
  • Qiang Sun,
  • Xingxu Huang

DOI
https://doi.org/10.1038/s41467-018-04768-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.