FEATURES IMMUNOHISTOCHEMICAL EXPRESSION CHANGES IN PLACENTAL PROGESTERONE RECEPTOR STRUCTURES IN PRETERM LABOR IN WOMEN WITH A MULTIPLE PREGNANCY OF ASSISTED REPRODUCTIVE TECHNOLOGIES

Abstract

Summary: Multiple pregnancy refers to the high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. Hormonal disorders are one of the major causes of miscarriage and preterm birth in multiple pregnancies resulting from assisted reproductive technologies (ART). Progesterone and the number of its receptors play an important role in preserving and prolonging pregnancy being relevant scientific direction. We have clinical and statistical analysis of the course of pregnancy, childbirth in women with multiple pregnancies resulting from assisted reproduction. In order to determine the ability of eksperesuyuchschey progesterone receptor, performed immunohistochemical study of 94 women with placenta bihorialnoy, biamnioticheskoy twins due to VRT. During the study it found that women with a multiple pregnancy due to ART are burdened somatic and obstetric and gynecological history, which had a negative effect on the impact and outcome of pregnancy. Morbidity during pregnancy is not only reflected on the nature of the flow of labor, but also in terms of delivery as well as prematurity with multiple pregnancy occur in 2 times more often than in singleton pregnancies. Immunohistochemical study of placentas was viyavileno greatest expression of progesterone receptors in the nuclei of decidual cells (45%) related to the parent structure of the placenta from women with a multiple pregnancy caused by ART. These results point to a definitive link structures placental endometrial relations, as an important component of the advisability of administering progesterone therapy.

Keywords

• premature labor, progesterone receptors, placenta, immunohistochemistry, multiple pregnancy, art.