Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination

Jianjian Hu; Wenxue Jiang; Jiaqi Zuo; Dujuan Shi; Xiaoqi Chen; Xiao Yang; Wenhui Zhang; Lixin Ma; Zhu Liu; Qiong Xing

doi:10.1038/s42003-023-04458-1

Communications Biology (Jan 2023)

Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination

Jianjian Hu,
Wenxue Jiang,
Jiaqi Zuo,
Dujuan Shi,
Xiaoqi Chen,
Xiao Yang,
Wenhui Zhang,
Lixin Ma,
Zhu Liu,
Qiong Xing

Affiliations

Jianjian Hu: National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University
Wenxue Jiang: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Jiaqi Zuo: National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University
Dujuan Shi: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Xiaoqi Chen: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Xiao Yang: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Wenhui Zhang: National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University
Lixin Ma: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Zhu Liu: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University
Qiong Xing: State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University

DOI: https://doi.org/10.1038/s42003-023-04458-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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Structural and mutagenic analyses reveal the mechanistic basis of azurin-mediated p53 stabilization and tumor suppression, and several affinity-enhancing azurin mutants are designed.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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