Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

Keiken Ri; Hyeon-Cheol Lee-Okada; Takehiko Yokomizo

doi:10.1038/s42003-022-03972-y

Communications Biology (Sep 2022)

Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

Keiken Ri,
Hyeon-Cheol Lee-Okada,
Takehiko Yokomizo

Affiliations

Keiken Ri: Department of Biochemistry, Juntendo University Graduate School of Medicine
Hyeon-Cheol Lee-Okada: Department of Biochemistry, Juntendo University Graduate School of Medicine
Takehiko Yokomizo: Department of Biochemistry, Juntendo University Graduate School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03972-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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Leydig cells highly express FADS2 to facilitate male steroid hormone production by accumulating omega-6 HUFA-containing cholesteryl esters, which serve as preferred substrates for hormone-sensitive lipase

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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