Case Reports in Infectious Diseases (Jan 2013)
Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections
Abstract
Treatment of Scedosporium apiospermum central nervous system (CNS) infection typically consists of an azole in combination with surgical debridement. This approach requires prolonged treatment and carries a high associated mortality. We present two cases of the successful treatment of S. apiospermum CNS infections with the combination of voriconazole and terbinafine.