Hericium caput-medusae (Bull.: Fr.) Pers. Fermentation concentrate polysaccharide ameliorate diarrhea in DSS-induced early colitis by modulating ion channel

Abstract

Diarrhea with physical weakness is a highly prevalent symptom in patients with inflammatory bowel disease. Based on the dextran sodium sulfate (DSS) -induced mouse ulcerative colitis model, the present study was undertaken to investigate the effect and the possible mechanism of Hericium caput-medusae (Bull.: Fr.) Pers. fermentation concentrate polysaccharide (HFP) on diarrhea in mice. HFP alleviated DSS-induced symptoms in ulcerative colitis mice, including elevated body weight, increased colonic length as well as mucus layer thickness, and relief of diarrhea. Daily assays revealed that HFP regulated the expression and activity of intestinal ion transport proteins as well as alleviated inflammation. HFP could also reduce the rate of intestinal transit and improved the expression of the tight junction. In summary, HFP had a palliative effect on diarrhea in DSS-induced preliminary stage of ulcerative colitis, which basically make HFP a promising drug for the relief of ulcerative colitis diarrhea.

Keywords

• Polysaccharide
• Diarrhea
• Ion transport
• Inflammatory mediators
• Intestinal transit
• Tight junction